DB Engine :: Removing Unused NC Indexes From Subscriber Database

We have transaction replication set up on one of our servers whose replicated DB is used for reporting purpose:

Now, the replicated database "D" of size 350 GB has mainly grown huge as compared to Published DB (200 GB) because of the index sizes at subscribed DB. Therefore:

I have found that Database D has one table of data size 15 GB, with rows 8349533 and index size 28 GB the biggest in the database. And adding have total of 109 Non clustered indexes:

On using SP_blitzindex i have found approx 50 NC indexes unused with below usage:

Reads: 0 Writes:273,243 and total size of indexes being 18 GB

Last User Seek
Last User Scan

Last User Lookup all '0' 
0 singleton lookups; 0 scans/seeks; 0 deletes; 0 updates; 
except for few 3 or 4 where updates are more than 4000.

Is this sufficient enough to delete all the above 49 unused NC indexes? And Can i create Missing index on Subscriber database?